Hemoglobinopathies, in particular sickle cell disease, is the most prevalent group of genetically transmitted diseases in the Brazilian population and should thus be treated as a public health problem.Many of these patients frequently present with complications and require emergency care at Pepper Shaker the blood bank Coordinator in Rio de Janeiro
Antisense oligonucleotide (AO) therapy has been the specific treatment for Duchenne muscular dystrophy, with ongoing clinical trials.However, therapeutic applications of AOs remain limited, particularly because of the lack of efficient cellular delivery methods imperative for achieving efficacy.In this study, we investigated a few aminoglycosides (
We describe females and males of Osmia (Melanosmia) calaminthae sp.n., an apparent floral specialist on Calamintha ashei (Lamiaceae), and provide observations on the behavior of female bees on flowers of this plant.We also provide diagnostic information for Osmia (Diceratosmia) conjunctoides Robertson, stat.n., and synonymize ECHINACEA LOZENGES O.(